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A doação pode ser voluntária (para qualquer pessoa) e para irmãos.
Quando os pais de um bebê recém-nascido doam o sangue do cordão umbilical para um Banco Público, o material pode ser utilizado por qualquer paciente que necessite de um doador para realizar o transplante.
Existe ainda, em bancos públicos, a modalidade de doação familiar direcionada. Nesse caso, o sangue do cordão umbilical pode ser utilizado em benefício de um irmão doente que precise do transplante.
